Showing posts with label vaccine. Show all posts
Showing posts with label vaccine. Show all posts

Thursday, September 11, 2008

Universal flu vaccine and human Guinea Pigs!



Human trials of universal flu vaccine begin from PhysOrg.com

Clinical trials of a new vaccine that could protect against multiple types of flu are beginning at Oxford University. If successful, the ‘universal’ flu injection would transform the way we vaccinate against influenza and could offer immunity to a bird flu pandemic.

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The problem with the Influenza Virus (the Flu virus) is that it changes over time. Small changes lead to drift and normally cause epidemics while more substantial changes, also know as gene shift, may cause dreaded pandemics. The problem with the flu vaccine is that it targets special protein found at the surface of the virus and that shift and drift creates "new viruses" no longer recognized by our immune system. So there...you need a shot every year...AND YOU SHOULD GET IT!

The problem with yearly shots is that new vaccine production is mainly based on statistics and the probability to find such and such strain in any given year. This is normally based on the study of previous years. In a way, it can sometimes be a long shot. Having said that, even with the uncertainty these shots can prove to be useful.

Many people do not want to be inoculated with vaccines for various reasons including the fact that some vaccines contain Thimerosal, a mercury-containing preservative, even if Thimerosal has been proven to be eliminated very quickly by the organism even in infants.

The bird flu that, so far, has killed close to 200 people worldwide reminds us that a pandemic is more a question of "when" than of "if" and the scientific community is trying its best to come up with a solution. The main problem in the production of a new vaccine against a probable bird flu pandemic is that we need the virus before we can produce a vaccine...in other words, we need the pandemic to start before we can inoculate people. The other problem is that vaccine production takes a lot of effort and the industrial capacity worldwide is limited. We would NOT have enough vaccines for everyone on the planet!

A new vaccine seems promising and would likely address many problems related to yearly vaccine production. A universal vaccine targeting ALL strains of influenza. WOW! That is a real need! On September 8th, human clinical trials started with a limited cohort of brave human Guinea pigs. This study, done at the Oxford university, could lead the way to a new and much needed vaccine. Read more HERE

Image source: http://www.flickr.com/photos/gustavocarrijo/12181990/

Thursday, November 23, 2006

Polio....still around after all those years? YUP!

I am teaching microbiology. We are presently in our virology section...and year after year I say the same thing...poliovirus will be eradicated...one day! The thing is that cases have gone up in 2006 in comparison to 2005...but the good news is that the increase was felt only in endemic countries. For instance here are some interesting numbers:

  • Endemic countries 2005: 1528 cases
  • Endemic countries 2006: 1686 cases
  • Non-endemic countries 2005: 873 cases
  • Non-endemic countries 2006: 108 cases
These numbers are interesting because they seem to show that vaccination in some countries is actually working. Some of the non-endemic countries were endemic decades ago. OK, vaccination works, but why is it that this disease is still around? I do not have the answer to that but the World Health Organization (WHO) with a new leader in Dr. Margaret Chan might, this time, succeed. In her speech she mentionned:" We will complete polio eradication".

I hope this terribly delibitating disease will be wiped off the surface of our planet....soon!